HCID 178452634, Verbindung → HCID 178512234, Verbindung

HRID 1801512Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1801512
[C:1]([N:3]=[C:4]([O:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[NH:5][C:6]1[CH:7]=[CH:8][C:9]2[CH2:15][CH2:14][CH:13]([NH:16]C(OC(C)(C)C)=O)[CH2:12][CH2:11][C:10]=2[CH:24]=1)#[N:2]>C(O)(C)C.[H][H].[Pd]>[C:1]([N:3]=[C:4]([O:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[NH:5][C:6]1[CH:7]=[CH:8][C:9]2[CH2:15][CH2:14][C@H:13]([NH2:16])[CH2:12][CH2:11][C:10]=2[CH:24]=1)#[N:2]

Komponenten

4

Edukt 1

HCID 178452634HCID 178452634, Verbindung

Produkt 1

HCID 178512234HCID 178512234, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178506449HCID 178506449, VerbindungKatalysatorHCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

The single enantiomer was then BOC-protected, the nitro group reduced by treatment with H2/Pd and the primary aniline treated with diphenyl cyanocarboimidate (slight excess) in 20 mL of isopropanol with stirring at ambient temperature overnight. The solid was filtered, washed with isopropanol and ether and dried to give phenyl (7S)-N′-cyano-N-(7-amino-6,7,8,9-tetrahydro-5H-benzo[7]annulene-2-yl)carbamimidate, as a white solid in high yield (from the single enantiomer via transamination).

Aufarbeitung

  1. filtrationThe solid was filtered
  2. washwashed with isopropanol and ether
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-5b34f1d15bbb4d13a07ec5ca2475c0b9
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08349838B2

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