Hydrochloric Acid → HCID 25227126, Verbindung

HRID 1802459Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1802459
[C:1]([C:5]1[CH:6]=[CH:7][C:8]([CH3:28])=[C:9]([NH:11][C:12]2[C:21]3[C:16](=[C:17](Cl)[N:18]=[CH:19][CH:20]=3)[C:15]3[CH:23]=[C:24]([F:27])[CH:25]=[CH:26][C:14]=3[N:13]=2)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].Cl.C([O-])(O)=[O:31].[Na+]>C1COCC1>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([CH3:28])=[C:9]([NH:11][C:12]2[C:21]3[CH:20]=[CH:19][NH:18][C:17](=[O:31])[C:16]=3[C:15]3[CH:23]=[C:24]([F:27])[CH:25]=[CH:26][C:14]=3[N:13]=2)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 59436103N-(5-tert-Butyl-2-methylphenyl)-1-chloro-9-fluorobenzo[c]-2,6-naphthyridin-5-amine

Produkt 1

HCID 25227126HCID 25227126, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

N-(5-tert-butyl-2-methylphenyl)-1-chloro-9-fluorobenzo[c]-2,6-naphthridin-5-amine (110 mg, 0.28 mmol) was taken up in THF (3.5 mL) and 6 N HCl (3.5 mL) and heated to 85° C. for 2 hr. The reaction was cooled to room temperature, neutralized with saturated NaHCO3 and extracted with EtOAc. The organic layers were dried over Mg2SO4, filtered, and concentrated. Column chromatography on silica gel (100% hexane to 100% EtOAc) provided the title compound.

Aufarbeitung

  1. extractionextracted with EtOAc
  2. dry with materialThe organic layers were dried over Mg2SO4
  3. filtrationfiltered
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-0bbae645fa5c4700a714cda29533945f
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08349865B2

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