Ammonia → 1-(3-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)thiourea

HRID 1803145Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1803145
[NH3:1].[N:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]=[N:13][N:14]([CH3:16])[CH:15]=2)=[C:7]([O:17][CH3:18])[CH:6]=1)=[C:3]=[S:4]>>[CH3:18][O:17][C:7]1[CH:6]=[C:5]([NH:2][C:3]([NH2:1])=[S:4])[CH:10]=[CH:9][C:8]=1[C:11]1[CH:12]=[N:13][N:14]([CH3:16])[CH:15]=1

Komponenten

3

Edukt 2

HCID 222AmmoniaHCID 866499074-(4-isothiocyanato-2-methoxyphenyl)-1-methyl-1H-pyrazole

Produkt 1

HCID 866499081-(3-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)thioureaAusbeute 86,5 %

Versuchsvorschrift

Step K (4): Methanolic ammonia (2.0 M, 20 mL, 40 mmol) was added to a flask charged with 4-(4-isothiocyanato-2-methoxyphenyl)-1-methyl-1H-pyrazole (1.46 g, 5.95 mmol). After 3 h, the reaction mixture was concentrated in vacuo. The solid was triturated with diethyl ether. The solid was collected by vacuum filtration and dried under high vacuum to afford 1-(3-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)thiourea (1.35 g, 86% yield). LC-MS (M+H)+ 263.1.

Aufarbeitung

  1. concentrationthe reaction mixture was concentrated in vacuo
  2. customThe solid was triturated with diethyl ether
  3. filtrationThe solid was collected by vacuum filtration
  4. customdried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-1867edefc8ae481fa0338eba781a3c70
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08349880B2

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