6-Amino-3-chloropyridazine → 6-Chloro-2-phenyl-3-pyrid-4-ylimidazo[1,2-b]pyridazine

HRID 1803902

Reaktionsgleichung

Reaktionsgleichung von HRID 1803902
Br[CH:2]([C:11]1[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=1)[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.[Cl:17][C:18]1[N:23]=[N:22][C:21]([NH2:24])=[CH:20][CH:19]=1>C(O)C>[Cl:17][C:18]1[CH:19]=[CH:20][C:21]2[N:22]([C:2]([C:11]3[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=3)=[C:3]([C:5]3[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:24]=2)[N:23]=1

Komponenten

4

Edukt 2

HCID 216436-Amino-3-chloropyridazineHCID 134660102-Bromo-1-phenyl-2-pyrid-4-ylethanone

Produkt 1

HCID 594069546-Chloro-2-phenyl-3-pyrid-4-ylimidazo[1,2-b]pyridazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 13 g (36.5 mmol) of 2-bromo-1-phenyl-2-pyrid-4-ylethanone (CAS No.: 741633-76-1) and 18.9 g (146 mmol) of 6-chloropyridazin-3-ylamine in 200 mL of ethanol is maintained at 90° C. for 5 hours 30 minutes. After cooling, the solvent is evaporated off under reduced pressure, the medium is taken up in 50 mL of water and the product is extracted with ethyl acetate. The organic phases are dried over magnesium sulfate and then concentrated under reduced pressure.

Aufarbeitung

  1. temperatureAfter cooling
  2. customthe solvent is evaporated off under reduced pressure
  3. extractionthe product is extracted with ethyl acetate
  4. dry with materialThe organic phases are dried over magnesium sulfate
  5. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-5798ccd6960f43ff83510bf5c188a427
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354405B2

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