(R)-4-Methyloxazolidin-2-one → (R)-3-methoxy-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid

HRID 1803979

Reaktionsgleichung

Reaktionsgleichung von HRID 1803979
Br[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=[O:7])=[CH:4][C:3]=1[O:12][CH3:13].[CH3:14][C@@H:15]1[CH2:19][O:18][C:17](=[O:20])[NH:16]1>>[CH3:13][O:12][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:2]=1[N:16]1[C@H:15]([CH3:14])[CH2:19][O:18][C:17]1=[O:20])[C:6]([OH:8])=[O:7]

Komponenten

3

Edukt 2

HCID 2734858(R)-4-Methyloxazolidin-2-oneHCID 14570117Methyl 4-bromo-3-methoxybenzoate

Produkt 1

HCID 58484801(R)-3-methoxy-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acidAusbeute 97,5 %

Versuchsvorschrift

By reaction and treatment in the same manner as in Preparation Example 45 and using methyl 4-bromo-3-methoxybenzoate (1 g) and (R)-4-methyloxazolidin-2-one (607 mg) described in Preparation Example 25, the title compound (1 g) was obtained.

Aufarbeitung

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 45
  3. customdescribed in Preparation Example 25

Quellen und Nachweise

ORD-Eintrag
ord-dfc5d763c3244908b695e300cb61484a
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354401B2

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