Ethyl 4-iodobenzoate → (R)-4-(2-oxo-4-propyloxazolidin-3-yl)benzoic acid

Reaktionsgleichung

I[C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8]CC)=[O:7])=[CH:4][CH:3]=1.[CH2:13]([C@@H:16]1[CH2:20][O:19][C:18](=[O:21])[NH:17]1)[CH2:14][CH3:15]>>[CH2:13]([C@@H:16]1[CH2:20][O:19][C:18](=[O:21])[N:17]1[C:2]1[CH:3]=[CH:4][C:5]([C:6]([OH:8])=[O:7])=[CH:11][CH:12]=1)[CH2:14][CH3:15]

Komponenten

Edukt 2

HCID 142891Ethyl 4-iodobenzoate

HCID 2734859(4R)-4-Propyl-2-oxazolidinone

Produkt 1

HCID 58484846(R)-4-(2-oxo-4-propyloxazolidin-3-yl)benzoic acid

Versuchsvorschrift

By reaction and treatment in the same manner as in Preparation Example 18 and using ethyl 4-iodobenzoate (3.2 mL) and (R)-4-propyloxazolidin-2-one (2.5 g) described in Preparation Example 29, the title compound (5.7 g) was obtained.

Aufarbeitung

customBy reaction and treatment in the same manner
customas in Preparation Example 18
customdescribed in Preparation Example 29

Quellen und Nachweise

ORD-Eintrag: ord-846ed9f5f6aa4559b318bb374851e081
Quelldatensatz: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08354401B2

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