(R)-4-Methyloxazolidin-2-one → methyl (R)-3-fluoro-4-(4-methyl-2-oxooxazolidin-3-yl)benzoate

HRID 1804028

Reaktionsgleichung

Reaktionsgleichung von HRID 1804028
Br[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[F:12].[CH3:13][C@@H:14]1[CH2:18][O:17][C:16](=[O:19])[NH:15]1>>[F:12][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:2]=1[N:15]1[C@H:14]([CH3:13])[CH2:18][O:17][C:16]1=[O:19])[C:6]([O:8][CH3:9])=[O:7]

Komponenten

3

Edukt 2

HCID 2734858(R)-4-Methyloxazolidin-2-oneHCID 21951878Methyl 4-bromo-3-fluorobenzoate

Produkt 1

HCID 58484559methyl (R)-3-fluoro-4-(4-methyl-2-oxooxazolidin-3-yl)benzoateAusbeute 92 %

Versuchsvorschrift

By reaction and treatment in the same manner as in Preparation Example 12 and using methyl 4-bromo-3-fluorobenzoate (1.2 g) and (R)-4-methyloxazolidin-2-one (607 mg) described in Preparation Example 25, the title compound (1.2 g) was obtained.

Aufarbeitung

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 12
  3. customdescribed in Preparation Example 25

Quellen und Nachweise

ORD-Eintrag
ord-dcd11aec23964959813ce4c5b17fd4e6
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354401B2

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