(R)-4-Methyloxazolidin-2-one → methyl (R)-3-methyl-4-(4-methyl-2-oxooxazolidin-3-yl)benzoate

HRID 1804029

Reaktionsgleichung

Reaktionsgleichung von HRID 1804029
Br[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[CH3:12].[CH3:13][C@@H:14]1[CH2:18][O:17][C:16](=[O:19])[NH:15]1>>[CH3:12][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:2]=1[N:15]1[C@H:14]([CH3:13])[CH2:18][O:17][C:16]1=[O:19])[C:6]([O:8][CH3:9])=[O:7]

Komponenten

3

Edukt 2

HCID 2734858(R)-4-Methyloxazolidin-2-oneHCID 3294148Methyl 4-bromo-3-methylbenzoate

Produkt 1

HCID 58484849methyl (R)-3-methyl-4-(4-methyl-2-oxooxazolidin-3-yl)benzoateAusbeute 100,3 %

Versuchsvorschrift

By reaction and treatment in the same manner as in Preparation Example 12 and using methyl 4-bromo-3-methylbenzoate (1.1 g) and (R)-4-methyloxazolidin-2-one (607 mg) described in Preparation Example 25, the title compound (1.2 g) was obtained.

Aufarbeitung

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 12
  3. customdescribed in Preparation Example 25

Quellen und Nachweise

ORD-Eintrag
ord-2633152adc6e4e22b3eb0d9ed530f9c3
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354401B2

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