4-Bromo-2-(methylsulfonamido)benzoic acid → N-{5-bromo-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}methanesulfonamide

HRID 1804071Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1804071
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([NH:11][S:12]([CH3:15])(=[O:14])=[O:13])[CH:3]=1.[CH:16]1([C:19]2[CH:20]=[C:21]([CH3:31])[C:22]([N:25]3[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]3)=[N:23][CH:24]=2)[CH2:18][CH2:17]1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:28]2[CH2:29][CH2:30][N:25]([C:22]3[C:21]([CH3:31])=[CH:20][C:19]([CH:16]4[CH2:17][CH2:18]4)=[CH:24][N:23]=3)[CH2:26][CH2:27]2)=[O:8])=[C:4]([NH:11][S:12]([CH3:15])(=[O:14])=[O:13])[CH:3]=1

Komponenten

3

Edukt 2

HCID 226210824-Bromo-2-(methylsulfonamido)benzoic acidHCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine

Produkt 1

HCID 58484826N-{5-bromo-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}methanesulfonamideAusbeute 79,9 %

Versuchsvorschrift

By reaction and treatment in the same manner as in Preparation Example 60 and using 4-bromo-2-methanesulfonylaminobenzoic acid (1 g) described in Preparation Example 122 and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (0.739 g) described in Preparation Example 96, the title compound (1.34 g) was obtained.

Aufarbeitung

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 60
  3. customdescribed in Preparation Example 96

Quellen und Nachweise

ORD-Eintrag
ord-af639e5b078c45e0b3c8189853346b88
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354401B2

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