6-Bromonicotinic acid → (6-Bromopyridin-3-yl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

HRID 1804096Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1804096
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH2:11]([C:13]1[CH:14]=[C:15]([CH3:25])[C:16]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[N:17][CH:18]=1)[CH3:12]>>[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([N:22]2[CH2:23][CH2:24][N:19]([C:16]3[C:15]([CH3:25])=[CH:14][C:13]([CH2:11][CH3:12])=[CH:18][N:17]=3)[CH2:20][CH2:21]2)=[O:8])=[CH:9][CH:10]=1

Komponenten

3

Edukt 2

HCID 2389326-Bromonicotinic acidHCID 584845781-(5-Ethyl-3-methylpyridin-2-yl)piperazine

Produkt 1

HCID 58484652(6-Bromopyridin-3-yl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanoneAusbeute 55 %

Versuchsvorschrift

By reaction and treatment in the same manner as in Preparation Example 27 and using 6-bromonicotinic acid (500 mg) and 1-(5-ethyl-3-methylpyridin-2-yl)piperazine (586 mg) described in Preparation Example 53, the title compound (530 mg) was obtained.

Aufarbeitung

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 27
  3. customdescribed in Preparation Example 53

Quellen und Nachweise

ORD-Eintrag
ord-29e6667415b34ba8be974f50742ce8a3
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354401B2

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