4-Iodobenzoyl chloride → [4-(5-Ethyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

HRID 1804122Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1804122
[CH2:1]([C:3]1[CH:4]=[C:5]([CH3:15])[C:6]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[N:7][CH:8]=1)[CH3:2].[I:16][C:17]1[CH:25]=[CH:24][C:20]([C:21](Cl)=[O:22])=[CH:19][CH:18]=1>>[CH2:1]([C:3]1[CH:4]=[C:5]([CH3:15])[C:6]([N:9]2[CH2:10][CH2:11][N:12]([C:21]([C:20]3[CH:24]=[CH:25][C:17]([I:16])=[CH:18][CH:19]=3)=[O:22])[CH2:13][CH2:14]2)=[N:7][CH:8]=1)[CH3:2]

Komponenten

3

Edukt 2

HCID 743734-Iodobenzoyl chlorideHCID 584845781-(5-Ethyl-3-methylpyridin-2-yl)piperazine

Produkt 1

HCID 58484605[4-(5-Ethyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanoneAusbeute 90,5 %

Versuchsvorschrift

By reaction and treatment in the same manner as in Preparation Example 161 and using 1-(5-ethyl-3-methylpyridin-2-yl)piperazine (2.46 g) described in Preparation Example 53 and 4-iodobenzoyl chloride (3.36 g), the title compound (4.72 g) was obtained.

Aufarbeitung

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 161

Quellen und Nachweise

ORD-Eintrag
ord-3362696b3ae9429bbdabe7882674a502
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354401B2

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