4-Bromo-2-fluorobenzoic acid → (4-Bromo-2-fluorophenyl)[4-(5-cyclopropylpyridin-2-yl)piperazin-1-yl]methanone

HRID 1804131Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1804131
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([F:11])[CH:3]=1.[CH:12]1([C:15]2[CH:16]=[CH:17][C:18]([N:21]3[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]3)=[N:19][CH:20]=2)[CH2:14][CH2:13]1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:24]2[CH2:25][CH2:26][N:21]([C:18]3[CH:17]=[CH:16][C:15]([CH:12]4[CH2:14][CH2:13]4)=[CH:20][N:19]=3)[CH2:22][CH2:23]2)=[O:8])=[C:4]([F:11])[CH:3]=1

Komponenten

3

Edukt 2

HCID 3026814-Bromo-2-fluorobenzoic acidHCID 584848401-(5-Cyclopropylpyridin-2-yl)piperazine

Produkt 1

HCID 58484657(4-Bromo-2-fluorophenyl)[4-(5-cyclopropylpyridin-2-yl)piperazin-1-yl]methanoneAusbeute 85,3 %

Versuchsvorschrift

By reaction and treatment in the same manner as in Preparation Example 90 and using 4-bromo-2-fluorobenzoic acid (1.2 g) and 1-(5-cyclopropylpyridin-2-yl)piperazine (1.02 g) described in Preparation Example 187, the title compound (1.73 g) was obtained.

Aufarbeitung

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 90
  3. customdescribed in Preparation Example 187

Quellen und Nachweise

ORD-Eintrag
ord-d323194e6b454d2b92ac0cc876454b07
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354401B2

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