4-Bromo-2,6-difluorobenzoic acid → (4-Bromo-2,6-difluorophenyl)[4-(5-cyclopropylpyridin-2-yl)piperazin-1-yl]methanone

HRID 1804132Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1804132
[Br:1][C:2]1[CH:10]=[C:9]([F:11])[C:5]([C:6]([OH:8])=O)=[C:4]([F:12])[CH:3]=1.[CH:13]1([C:16]2[CH:17]=[CH:18][C:19]([N:22]3[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]3)=[N:20][CH:21]=2)[CH2:15][CH2:14]1>>[Br:1][C:2]1[CH:3]=[C:4]([F:12])[C:5]([C:6]([N:25]2[CH2:26][CH2:27][N:22]([C:19]3[CH:18]=[CH:17][C:16]([CH:13]4[CH2:15][CH2:14]4)=[CH:21][N:20]=3)[CH2:23][CH2:24]2)=[O:8])=[C:9]([F:11])[CH:10]=1

Komponenten

3

Edukt 2

HCID 27732984-Bromo-2,6-difluorobenzoic acidHCID 584848401-(5-Cyclopropylpyridin-2-yl)piperazine

Produkt 1

HCID 58484548(4-Bromo-2,6-difluorophenyl)[4-(5-cyclopropylpyridin-2-yl)piperazin-1-yl]methanoneAusbeute 88,9 %

Versuchsvorschrift

By reaction and treatment in the same manner as in Preparation Example 90 and using 4-bromo-2,6-difluorobenzoic acid (1.20 g) and 1-(5-cyclopropylpyridin-2-yl)piperazine (1.15 g) described in Preparation Example 187, the title compound (1.90 g) was obtained.

Aufarbeitung

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 90
  3. customdescribed in Preparation Example 187

Quellen und Nachweise

ORD-Eintrag
ord-527e661c79384a75a53ea16f4a69c358
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354401B2

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