1-(3,5-Dimethylpyridin-2-yl)piperazine → 5-Bromo-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile

HRID 1804136Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1804136
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([C:11]#[N:12])[CH:3]=1.[CH3:13][C:14]1[C:15]([N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[N:16][CH:17]=[C:18]([CH3:20])[CH:19]=1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:24]2[CH2:25][CH2:26][N:21]([C:15]3[C:14]([CH3:13])=[CH:19][C:18]([CH3:20])=[CH:17][N:16]=3)[CH2:22][CH2:23]2)=[O:8])=[C:4]([CH:3]=1)[C:11]#[N:12]

Komponenten

3

Edukt 2

HCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazineHCID 584845854-Bromo-2-cyanobenzoic acid

Produkt 1

HCID 584846285-Bromo-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]benzonitrileAusbeute 83,1 %

Versuchsvorschrift

By reaction and treatment in the same manner as in Preparation Example 90 and using 4-bromo-2-cyanobenzoic acid (2.03 g) described in Preparation Example 192 and 1-(3,5-dimethylpyridin-2-yl)piperazine (1.81 g) described in Preparation Example 47, the title compound (2.98 g) was obtained.

Aufarbeitung

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 90
  3. customdescribed in Preparation Example 47

Quellen und Nachweise

ORD-Eintrag
ord-4c5d319daa99497f98bc75f7eec95ff2
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354401B2

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