4-(4-Methylphenoxy)piperidine → (R)-4-methyl-3-[4-(4-p-tolyloxypiperidine-1-carbonyl)phenyl]oxazolidin-2-one

HRID 1804182Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1804182
[C:1]1([CH3:14])[CH:6]=[CH:5][C:4]([O:7][CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:3][CH:2]=1.[CH3:15][C@@H:16]1[CH2:20][O:19][C:18](=[O:21])[N:17]1[C:22]1[CH:30]=[CH:29][C:25]([C:26](O)=[O:27])=[CH:24][CH:23]=1>>[CH3:15][C@@H:16]1[CH2:20][O:19][C:18](=[O:21])[N:17]1[C:22]1[CH:30]=[CH:29][C:25]([C:26]([N:11]2[CH2:12][CH2:13][CH:8]([O:7][C:4]3[CH:3]=[CH:2][C:1]([CH3:14])=[CH:6][CH:5]=3)[CH2:9][CH2:10]2)=[O:27])=[CH:24][CH:23]=1

Komponenten

3

Edukt 2

HCID 38374974-(4-Methylphenoxy)piperidineHCID 58484719(R)-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid

Produkt 1

HCID 67381285(R)-4-methyl-3-[4-(4-p-tolyloxypiperidine-1-carbonyl)phenyl]oxazolidin-2-oneAusbeute 77,6 %

Versuchsvorschrift

By reaction and treatment in the same manner as in Example 52 and using 4-(p-tolyloxy)piperidine (1 g) and (R)-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid (1.2 g) described in Preparation Example 37, the title compound (1.6 g) was obtained.

Aufarbeitung

  1. customBy reaction and treatment in the same manner as in Example 52
  2. customdescribed in Preparation Example 37

Quellen und Nachweise

ORD-Eintrag
ord-878a4ab351534d078c1b314cc1ef2612
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354401B2

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