(R)-4-(4-isopropyl-2-oxooxazolidin-3-yl)benzoic acid → (R)-3-{4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-isopropyloxazolidin-2-one

HRID 1804192Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1804192
Cl.[CH:2]1([C:5]2[CH:6]=[C:7]([CH3:17])[C:8]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)=[N:9][CH:10]=2)[CH2:4][CH2:3]1.[CH:18]([C@@H:21]1[CH2:25][O:24][C:23](=[O:26])[N:22]1[C:27]1[CH:35]=[CH:34][C:30]([C:31](O)=[O:32])=[CH:29][CH:28]=1)([CH3:20])[CH3:19]>>[CH:2]1([C:5]2[CH:6]=[C:7]([CH3:17])[C:8]([N:11]3[CH2:12][CH2:13][N:14]([C:31]([C:30]4[CH:29]=[CH:28][C:27]([N:22]5[C@H:21]([CH:18]([CH3:19])[CH3:20])[CH2:25][O:24][C:23]5=[O:26])=[CH:35][CH:34]=4)=[O:32])[CH2:15][CH2:16]3)=[N:9][CH:10]=2)[CH2:4][CH2:3]1

Komponenten

3

Edukt 2

HCID 58484694(R)-4-(4-isopropyl-2-oxooxazolidin-3-yl)benzoic acidHCID 673810911-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine hydrochloride

Produkt 1

HCID 67380778(R)-3-{4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-isopropyloxazolidin-2-oneAusbeute 42,5 %

Versuchsvorschrift

By reaction and treatment in the same manner as in Example 29 and using 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine hydrochloride (381 mg) described in Preparation Example 49 and (R)-4-(4-isopropyl-2-oxooxazolidin-3-yl)benzoic acid (374 mg) described in Preparation Example 18, the title compound (286 mg) was obtained.

Aufarbeitung

  1. customBy reaction and treatment in the same manner as in Example 29
  2. customdescribed in Preparation Example 18

Quellen und Nachweise

ORD-Eintrag
ord-55c3636361f740d28556b1608087f7ba
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354401B2

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