(R)-4-Methyloxazolidin-2-one → (R)-3-{3-chloro-4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-methyloxazolidin-2-one hydrochloride

HRID 1804212Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1804212
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[C:4]([Cl:24])[CH:3]=1.[CH3:25][C@@H:26]1[CH2:30][O:29][C:28](=[O:31])[NH:27]1>>[ClH:24].[Cl:24][C:4]1[CH:3]=[C:2]([N:27]2[C@H:26]([CH3:25])[CH2:30][O:29][C:28]2=[O:31])[CH:7]=[CH:6][C:5]=1[C:8]([N:10]1[CH2:15][CH2:14][N:13]([C:16]2[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=2)[CH2:12][CH2:11]1)=[O:9]

Komponenten

3

Edukt 2

HCID 2734858(R)-4-Methyloxazolidin-2-oneHCID 58484833(4-Bromo-2-chlorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

Produkt 1

HCID 67446415(R)-3-{3-chloro-4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-methyloxazolidin-2-one hydrochlorideAusbeute 30,9 %

Versuchsvorschrift

By reaction and treatment in the same manner as in Example 79 and using (4-bromo-2-chlorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (1.7 g) described in Preparation Example 69 and (R)-4-methyloxazolidin-2-one (510 mg) described in Preparation Example 25, the title compound (299 mg) was obtained.

Aufarbeitung

  1. customBy reaction and treatment in the same manner as in Example 79
  2. customdescribed in Preparation Example 25

Quellen und Nachweise

ORD-Eintrag
ord-9be0a5ad6570454d9642aa47d4e0422b
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354401B2

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