(R)-4-(4-isopropyl-2-oxooxazolidin-3-yl)benzoic acid → (R)-3-{4-[4-(3,5-dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-isopropyloxazolidin-2-one hydrochloride

HRID 1804226Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1804226
[CH:1]([C@@H:4]1[CH2:8][O:7][C:6](=[O:9])[N:5]1[C:10]1[CH:18]=[CH:17][C:13]([C:14]([OH:16])=O)=[CH:12][CH:11]=1)([CH3:3])[CH3:2].[ClH:19].[CH:20]1([C:23]2[C:24]([N:32]3[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]3)=[N:25][CH:26]=[C:27]([CH:29]3[CH2:31][CH2:30]3)[CH:28]=2)[CH2:22][CH2:21]1>>[ClH:19].[CH:20]1([C:23]2[C:24]([N:32]3[CH2:33][CH2:34][N:35]([C:14]([C:13]4[CH:12]=[CH:11][C:10]([N:5]5[C@H:4]([CH:1]([CH3:2])[CH3:3])[CH2:8][O:7][C:6]5=[O:9])=[CH:18][CH:17]=4)=[O:16])[CH2:36][CH2:37]3)=[N:25][CH:26]=[C:27]([CH:29]3[CH2:31][CH2:30]3)[CH:28]=2)[CH2:21][CH2:22]1

Komponenten

3

Edukt 2

HCID 58484694(R)-4-(4-isopropyl-2-oxooxazolidin-3-yl)benzoic acidHCID 673810941-(3,5-Dicyclopropylpyridin-2-yl)piperazine hydrochloride

Produkt 1

HCID 67381205(R)-3-{4-[4-(3,5-dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-isopropyloxazolidin-2-one hydrochlorideAusbeute 45,9 %

Versuchsvorschrift

By reaction and treatment in the same manner as in Example 87 and using (R)-4-(4-isopropyl-2-oxooxazolidin-3-yl)benzoic acid (499 mg) described in Preparation Example 18 and 1-(3,5-dicyclopropylpyridin-2-yl)piperazine hydrochloride (560 mg) described in Preparation Example 50, the title compound (469 mg) was obtained.

Aufarbeitung

  1. customBy reaction and treatment in the same manner as in Example 87
  2. customdescribed in Preparation Example 50

Quellen und Nachweise

ORD-Eintrag
ord-ead13ed37fa14d81acd2176f154d84be
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354401B2

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