(S)-5-methyloxazolidin-2-one → (S)-3-{4-[4-(3,5-dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-5-methyloxazolidin-2-one

HRID 1804246Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1804246
[CH:1]1([C:4]2[C:5]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([C:21]4[CH:26]=[CH:25][C:24](I)=[CH:23][CH:22]=4)=[O:20])[CH2:15][CH2:14]3)=[N:6][CH:7]=[C:8]([CH:10]3[CH2:12][CH2:11]3)[CH:9]=2)[CH2:3][CH2:2]1.[CH3:28][C@@H:29]1[O:33][C:32](=[O:34])[NH:31][CH2:30]1>>[CH:1]1([C:4]2[C:5]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([C:21]4[CH:26]=[CH:25][C:24]([N:31]5[CH2:30][C@H:29]([CH3:28])[O:33][C:32]5=[O:34])=[CH:23][CH:22]=4)=[O:20])[CH2:15][CH2:14]3)=[N:6][CH:7]=[C:8]([CH:10]3[CH2:12][CH2:11]3)[CH:9]=2)[CH2:3][CH2:2]1

Komponenten

3

Edukt 2

HCID 21794663(S)-5-methyloxazolidin-2-oneHCID 58484688[4-(3,5-Dicyclopropylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

Produkt 1

HCID 67380974(S)-3-{4-[4-(3,5-dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-5-methyloxazolidin-2-oneAusbeute 76,9 %

Versuchsvorschrift

By reaction and treatment in the same manner as in Example 149 and using [4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (473 mg) described in Preparation Example 95 and (S)-5-methyloxazolidin-2-one (121 mg) described in Preparation Example 42, the title compound (343 mg) was obtained.

Aufarbeitung

  1. customBy reaction and treatment in the same manner as in Example 149
  2. customdescribed in Preparation Example 42

Quellen und Nachweise

ORD-Eintrag
ord-4199f1484e5f4fb9bb02b34c60d3ffbc
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354401B2

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