(4S)-4-(Benzoyloxymethyl)oxazolidine-2-one → (R)-3-{5-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}-4-hydroxymethyloxazolidin-2-one

HRID 1804318

Reaktionsgleichung

Reaktionsgleichung von HRID 1804318
Br[C:2]1[N:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[O:24]=[C:25]1[NH:29][C@H:28]([CH2:30][O:31]C(=O)C2C=CC=CC=2)[CH2:27][O:26]1>>[CH3:22][C:21]1[C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:8]([C:5]3[CH:4]=[CH:3][C:2]([N:29]4[C@H:28]([CH2:30][OH:31])[CH2:27][O:26][C:25]4=[O:24])=[N:7][CH:6]=3)=[O:9])[CH2:11][CH2:12]2)=[N:17][CH:18]=[C:19]([CH3:23])[CH:20]=1

Komponenten

3

Edukt 2

HCID 16213752(4S)-4-(Benzoyloxymethyl)oxazolidine-2-oneHCID 58484661(6-Bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

Produkt 1

HCID 58484796(R)-3-{5-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}-4-hydroxymethyloxazolidin-2-oneAusbeute 64 %

Versuchsvorschrift

By reaction and treatment in the same manner as in Example 19 and using (6-bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (940 mg) described in Preparation Example 73 and benzoic acid (R)-2-oxooxazolidin-4-ylmethyl ester (814 mg), the title compound (660 mg) was obtained.

Aufarbeitung

  1. customBy reaction and treatment in the same manner as in Example 19

Quellen und Nachweise

ORD-Eintrag
ord-2caf49c413694aefb6b568ee022d515f
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354401B2

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