5,5-Dimethyloxazolin-2-one → 3-{4-[4-(3,5-Dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-5,5-dimethyloxazolidin-2-one

HRID 1804337Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1804337
[CH:1]1([C:4]2[C:5]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([C:21]4[CH:26]=[CH:25][C:24](I)=[CH:23][CH:22]=4)=[O:20])[CH2:15][CH2:14]3)=[N:6][CH:7]=[C:8]([CH:10]3[CH2:12][CH2:11]3)[CH:9]=2)[CH2:3][CH2:2]1.[CH3:28][C:29]1([CH3:35])[O:33][C:32](=[O:34])[N:31]=[CH:30]1>>[CH:1]1([C:4]2[C:5]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([C:21]4[CH:26]=[CH:25][C:24]([N:31]5[CH2:30][C:29]([CH3:35])([CH3:28])[O:33][C:32]5=[O:34])=[CH:23][CH:22]=4)=[O:20])[CH2:15][CH2:14]3)=[N:6][CH:7]=[C:8]([CH:10]3[CH2:12][CH2:11]3)[CH:9]=2)[CH2:3][CH2:2]1

Komponenten

3

Edukt 2

HCID 214647825,5-Dimethyloxazolin-2-oneHCID 58484688[4-(3,5-Dicyclopropylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

Produkt 1

HCID 584848433-{4-[4-(3,5-Dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-5,5-dimethyloxazolidin-2-oneAusbeute 28,5 %

Versuchsvorschrift

By reaction and treatment in the same manner as in Example 110 and using [4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (473 mg) described in Preparation Example 95 and 5,5-dimethyloxazolin-2-one (138 mg) described in Preparation Example 43, the title compound (131 mg) was obtained.

Aufarbeitung

  1. customBy reaction and treatment in the same manner as in Example 110
  2. customdescribed in Preparation Example 43

Quellen und Nachweise

ORD-Eintrag
ord-62255c3df904408fa51cac6595620ee5
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354401B2

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