5,5-Dimethyloxazolin-2-one → 3-{3-(1,1-Dioxoisothiazolidin-2-yl)-4-[4-(5-ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-5,5-dimethyloxazolidin-2-one

HRID 1804375Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1804375
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH2:23][CH3:24])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[C:4]([N:25]2[CH2:29][CH2:28][CH2:27][S:26]2(=[O:31])=[O:30])[CH:3]=1.[CH3:32][C:33]1([CH3:39])[O:37][C:36](=[O:38])[N:35]=[CH:34]1>>[O:30]=[S:26]1(=[O:31])[CH2:27][CH2:28][CH2:29][N:25]1[C:4]1[CH:3]=[C:2]([N:35]2[CH2:34][C:33]([CH3:39])([CH3:32])[O:37][C:36]2=[O:38])[CH:7]=[CH:6][C:5]=1[C:8]([N:10]1[CH2:15][CH2:14][N:13]([C:16]2[C:21]([CH3:22])=[CH:20][C:19]([CH2:23][CH3:24])=[CH:18][N:17]=2)[CH2:12][CH2:11]1)=[O:9]

Komponenten

3

Edukt 2

HCID 214647825,5-Dimethyloxazolin-2-oneHCID 58484567[4-Bromo-2-(1,1-dioxoisothiazolidin-2-yl)phenyl][4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

Produkt 1

HCID 584847203-{3-(1,1-Dioxoisothiazolidin-2-yl)-4-[4-(5-ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-5,5-dimethyloxazolidin-2-oneAusbeute 48,3 %

Versuchsvorschrift

By reaction and treatment in the same manner as in Example 110 and using [4-bromo-2-(1,1-dioxoisothiazolidin-2-yl)phenyl][4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (761 mg) described in Preparation Example 180 and 5,5-dimethyloxazolin-2-one (207 mg) described in Preparation Example 43, the title compound (392 mg) was obtained.

Aufarbeitung

  1. customBy reaction and treatment in the same manner as in Example 110
  2. customdescribed in Preparation Example 43

Quellen und Nachweise

ORD-Eintrag
ord-d67b0aef1454447884ab84ce99c96438
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354401B2

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