(R)-4-Methyloxazolidin-2-one → (R)-3-{4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]-3-(1,1-dioxoisothiazolidin-2-yl)phenyl}-4-methyloxazolidin-2-one

HRID 1804379Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1804379
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][C:17]=3[CH3:23])[CH2:12][CH2:11]2)=[O:9])=[C:4]([N:24]2[CH2:28][CH2:27][CH2:26][S:25]2(=[O:30])=[O:29])[CH:3]=1.[CH3:31][C@@H:32]1[CH2:36][O:35][C:34](=[O:37])[NH:33]1>>[CH3:23][C:17]1[CH:18]=[C:19]([CH3:22])[CH:20]=[CH:21][C:16]=1[N:13]1[CH2:14][CH2:15][N:10]([C:8]([C:5]2[CH:6]=[CH:7][C:2]([N:33]3[C@H:32]([CH3:31])[CH2:36][O:35][C:34]3=[O:37])=[CH:3][C:4]=2[N:24]2[CH2:28][CH2:27][CH2:26][S:25]2(=[O:30])=[O:29])=[O:9])[CH2:11][CH2:12]1

Komponenten

3

Edukt 2

HCID 2734858(R)-4-Methyloxazolidin-2-oneHCID 58484743[4-Bromo-2-(1,1-dioxoisothiazolidin-2-yl)phenyl][4-(2,4-dimethylphenyl)piperazin-1-yl]methanone

Produkt 1

HCID 58484815(R)-3-{4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]-3-(1,1-dioxoisothiazolidin-2-yl)phenyl}-4-methyloxazolidin-2-oneAusbeute 87,5 %

Versuchsvorschrift

By reaction and treatment in the same manner as in Example 149 and using [4-bromo-2-(1,1-dioxoisothiazolidin-2-yl)phenyl][4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (492 mg) described in Preparation Example 181 and (R)-4-methyloxazolidin-2-one (121 mg) described in Preparation Example 25, the title compound (448 mg) was obtained.

Aufarbeitung

  1. customBy reaction and treatment in the same manner as in Example 149
  2. customdescribed in Preparation Example 25

Quellen und Nachweise

ORD-Eintrag
ord-245718516c75474a95f7aee572171155
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354401B2

Notizen zur Reaktion

Wird geladen…