HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
(R)-4-Methyloxazolidin-2-one → (R)-3-{3-cyano-4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-methyloxazolidin-2-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | (R)-4-Methyloxazolidin-2-one | HCID 2734858 | — |
| Edukt | 5-Bromo-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile | HCID 58484573 | — |
| Produkt | (R)-3-{3-cyano-4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-methyloxazolidin-2-one | HCID 58484637 | — |
Reaktionsschritte
By reaction and treatment in the same manner as in Example 110 and using 5-bromo-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile (425 mg) described in Preparation Example 194 and (R)-4-methyloxazolidin-2-one. (121 mg) described in Preparation Example 25, the title compound (363 mg) was obtained.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08354401B2 |
| Quelldatensatz | uspto-grants-2013_01 |
| ORD ID | ord-9575450010384f0ab491d5e9c6440974 |
| Quellennotiz | uspto-grants-2013_01 |