1,3-Oxazol-2(5H)-one → 3-{3-Cyano-4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one

HRID 1804399Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1804399
Br[C:2]1[CH:3]=[CH:4][C:5]([C:10]([N:12]2[CH2:17][CH2:16][N:15]([C:18]3[C:23]([CH3:24])=[CH:22][C:21]([CH:25]4[CH2:27][CH2:26]4)=[CH:20][N:19]=3)[CH2:14][CH2:13]2)=[O:11])=[C:6]([CH:9]=1)[C:7]#[N:8].[O:28]1[CH2:32][CH:31]=[N:30][C:29]1=[O:33]>>[C:7]([C:6]1[CH:9]=[C:2]([N:30]2[CH2:31][CH2:32][O:28][C:29]2=[O:33])[CH:3]=[CH:4][C:5]=1[C:10]([N:12]1[CH2:17][CH2:16][N:15]([C:18]2[C:23]([CH3:24])=[CH:22][C:21]([CH:25]3[CH2:27][CH2:26]3)=[CH:20][N:19]=2)[CH2:14][CH2:13]1)=[O:11])#[N:8]

Komponenten

3

Edukt 2

HCID 144050941,3-Oxazol-2(5H)-oneHCID 584845735-Bromo-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile

Produkt 1

HCID 584845023-{3-Cyano-4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-oneAusbeute 81,6 %

Versuchsvorschrift

By reaction and treatment in the same manner as in Example 110 and using 5-bromo-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile (425 mg) described in Preparation Example 194 and oxazolin-2-one (104 mg), the title compound (352 mg) was obtained.

Aufarbeitung

  1. customBy reaction and treatment in the same manner as in Example 110

Quellen und Nachweise

ORD-Eintrag
ord-3d183af6723a4066bd548533bc4138d4
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354401B2

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