Ethyl p-(2-oxo-1,3-oxazolidin-3-yl)benzoate → 3-{4-[4-(2,6-Dimethylpyridin-3-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one

HRID 1804407

Reaktionsgleichung

Reaktionsgleichung von HRID 1804407
[O:1]=[C:2]1[N:6]([C:7]2[CH:17]=[CH:16][C:10]([C:11]([O:13]CC)=O)=[CH:9][CH:8]=2)[CH2:5][CH2:4][O:3]1.[CH3:18][C:19]1[C:24]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[CH:23][CH:22]=[C:21]([CH3:31])[N:20]=1>>[CH3:18][C:19]1[C:24]([N:25]2[CH2:30][CH2:29][N:28]([C:11]([C:10]3[CH:9]=[CH:8][C:7]([N:6]4[CH2:5][CH2:4][O:3][C:2]4=[O:1])=[CH:17][CH:16]=3)=[O:13])[CH2:27][CH2:26]2)=[CH:23][CH:22]=[C:21]([CH3:31])[N:20]=1

Komponenten

3

Edukt 2

HCID 616604Ethyl p-(2-oxo-1,3-oxazolidin-3-yl)benzoateHCID 584847031-(2,6-Dimethylpyridin-3-yl)piperazine

Produkt 1

HCID 584848113-{4-[4-(2,6-Dimethylpyridin-3-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-oneAusbeute 15,8 %

Versuchsvorschrift

By reaction and treatment in the same manner as in Example 34 and using ethyl 4-(2-oxooxazolidin-3-yl)benzoate (353 mg) described in Preparation Example 12 and 1-(2,6-dimethylpyridin-3-yl)piperazine (287 mg) described in Preparation Example 153, the title compound (90.2 mg) was obtained.

Aufarbeitung

  1. customBy reaction and treatment in the same manner as in Example 34
  2. customdescribed in Preparation Example 153

Quellen und Nachweise

ORD-Eintrag
ord-2f016fdd0c174f72b85a00e4faed29d4
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354401B2

Verknüpfte Notizen

Wird geladen…