Hydrochloric Acid → [2-(3-Isopropyl-1,2,4-oxadiazol-5-yl)ethyl]amine hydrochloride

HRID 1804569Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1804569
[CH:1]([C:4]1[N:8]=[C:7]([CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C)[O:6][N:5]=1)([CH3:3])[CH3:2].[ClH:19]>ClCCl>[ClH:19].[CH:1]([C:4]1[N:8]=[C:7]([CH2:9][CH2:10][NH2:11])[O:6][N:5]=1)([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 313Hydrochloric Acid2×HCID 57637051Tert-butyl[2-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-ethyl]-carbamate

Produkt 1

HCID 46737067[2-(3-Isopropyl-1,2,4-oxadiazol-5-yl)ethyl]amine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

900 mg (3.53 mmol) tert-butyl [2-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-ethyl]-carbamate are placed in 10 ml dichloromethane, 20 ml 1 molar ethereal hydrochloric acid are added. The reaction mixture is stirred for 16 hours at ambient temperature. After the further addition of 10 ml ethereal hydrochloric acid the mixture is stirred for another 72 hours at ambient temperature and 4 hours at 40° C. The suspension is evaporated down. The residue is dissolved in acetone, mixed with diethyl ether and suction filtered.

Aufarbeitung

  1. stirringis stirred for another 72 hours at ambient temperature and 4 hours at 40° C
  2. customThe suspension is evaporated down
  3. dissolutionThe residue is dissolved in acetone
  4. additionmixed with diethyl ether and suction
  5. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-bfc0e7f40ba745ce897ed442f9458fe1
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354418B2

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