Tert-butyl 4-(1,3-thiazol-4-yl)piperidine-1-carboxylate → 4-(1,3-Thiazol-4-yl)piperidine
Reaktionsgleichung
[S:1]1[CH:5]=[C:4]([CH:6]2[CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]2)[N:3]=[CH:2]1>Cl.O1CCOCC1>[S:1]1[CH:5]=[C:4]([CH:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[N:3]=[CH:2]1Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
The title compound from Step C above (280 mg, 1.04 mmol) was dissolved in 4 M HCl in dioxane (4.0 mL) and stirred at RT for 1 h. The product was concentrated under reduced pressure and dried under high vacuum to give the title compound (i-30) (237 mg, 94%). ESI-MS calculated for C8H12N2S: Exact Mass: 168.07. Found 169.07.
Aufarbeitung
- concentrationThe product was concentrated under reduced pressure
- customdried under high vacuum
Quellen und Nachweise
- ORD-Eintrag
- ord-bf3b05b113874f4195859adc25366651
- Quelldatensatz
- uspto-grants-2013_01
- Patentnummer
- US08354403B2
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