Cesium carbonate → Methyl 3-(difluoromethoxy)-4-nitrobenzoate

HRID 1804671Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1804671
[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[C:6]([OH:13])[CH:5]=1.C(=O)([O-])[O-].[Cs+].[Cs+].[F:21][CH:22]([F:24])I>CN(C=O)C>[F:21][CH:22]([F:24])[O:13][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][C:7]=1[N+:10]([O-:12])=[O:11])[C:3]([O:2][CH3:1])=[O:14]

Komponenten

5

Edukt 3

HCID 10796Cesium carbonateHCID 294866Methyl 3-hydroxy-4-nitrobenzoateHCID 2775155Difluoro(iodo)methane

Produkt 1

HCID 57969921Methyl 3-(difluoromethoxy)-4-nitrobenzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a cooled solution of 1 g of methyl-3-hydroxy-4-nitrobenzoate, 3.31 g of cesium carbonate in 20 mL of DMF, was carefully added 1.5 equivalents of difluoroiodomethane. The reaction was allowed to warm to room temperature and followed by TLC. Upon completion of the reaction, the mixture was concentrated and purified by silica get chromatography to give 1.2 g of methyl 3-(difluoromethoxy)-4-nitrobenzoate.

Aufarbeitung

  1. customUpon completion of the reaction
  2. concentrationthe mixture was concentrated
  3. custompurified by silica
  4. customget chromatography

Quellen und Nachweise

ORD-Eintrag
ord-66544f61697a4cf2845067c944d467ee
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354420B2

Notizen zur Reaktion

Wird geladen…