(-)-Dibenzoyltartrate → 2,2-Dimethyl-propionic acid (3S,4S)-3-methyl-piperidin-4-yl ester (-)-dibenzoyltartrate

HRID 1804761Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1804761
[CH3:1][CH:2]1[CH:7]([O:8][C:9](=[O:14])[C:10]([CH3:13])([CH3:12])[CH3:11])[CH2:6][CH2:5][NH:4][CH2:3]1.[C:15]([C:23]([C:38]([O-:40])=[O:39])([OH:37])[C:24]([C:29](=[O:36])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)([OH:28])[C:25]([O-:27])=[O:26])(=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C(OCC)(=O)C>[C:29]([C:24]([C:25]([OH:27])=[O:26])([OH:28])[C:23]([C:15](=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)([OH:37])[C:38]([OH:40])=[O:39])(=[O:36])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1.[CH3:1][C@@H:2]1[C@@H:7]([O:8][C:9](=[O:14])[C:10]([CH3:13])([CH3:12])[CH3:11])[CH2:6][CH2:5][NH:4][CH2:3]1

Komponenten

4

Edukt 2

HCID 21978704(-)-DibenzoyltartrateHCID 668421342,2-Dimethyl-propionic acid (3RS,4RS)-3-methyl-piperidin-4-yl ester

Produkt 1

HCID 1317301552,2-Dimethyl-propionic acid (3S,4S)-3-methyl-piperidin-4-yl ester (-)-dibenzoyltartrate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel2×

Versuchsvorschrift

2,2-Dimethyl-propionic acid (3RS,4RS)-3-methyl-piperidin-4-yl ester (5) (9.6 g, 48 mmol) is dissolved in 50 ml of ethyl acetate. A solution of (−)-dibenzoyltartrate (8.6 g, 24 mmol) in ethyl acetate is added drop wise. The precipitate is filtrated off and washed with cold ethyl acetate to yield colourless crystals.

Aufarbeitung

  1. filtrationThe precipitate is filtrated off
  2. washwashed with cold ethyl acetate
  3. customto yield colourless crystals

Quellen und Nachweise

ORD-Eintrag
ord-5dd345f6fc7e4ea281f841b92d6979a7
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354431B2

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