2-Amino-2-methylpropanamide hydrochloride → 2-[5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-5,5-dimethyl-3,5-dihydro-imidazol-4-one
Reaktionsgleichung
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[Cl:20])[N:11]=[C:10]([C:21](O)=O)[C:9]=2[CH2:24][CH3:25])=[CH:4][CH:3]=1.Cl.[NH2:27][C:28]([CH3:33])([CH3:32])[C:29]([NH2:31])=[O:30]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[Cl:20])[N:11]=[C:10]([C:21]3[NH:31][C:29](=[O:30])[C:28]([CH3:33])([CH3:32])[N:27]=3)[C:9]=2[CH2:24][CH3:25])=[CH:6][CH:7]=1Komponenten
3
Versuchsvorschrift
Compound 24 was synthesized from 4c (1.0 g, 2.53 mmol) and 5i (0.56 g, 4.07 mmol) as a white solid (0.58 g, 50%) in a manner similar to that described in Example 53. 1H NMR (400 MHz, CDCl3) δ 7.43 (d, 1H), 7.30 (d, 2H), 7.30˜7.27 (m, 2H), 7.07 (d, 2H), 7.00 (br s, 1H), 2.78 (q, 2H), 1.81 (s, 6H), 1.20 (t, 3H); ESMS m/z: 461.0 (M+1).