5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid → 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazol-3-yl]-1,3-diaza-spiro[4.4]non-1-en-4-one

HRID 1805203

Reaktionsgleichung

Reaktionsgleichung von HRID 1805203
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[Cl:20])[N:11]=[C:10]([C:21](O)=O)[C:9]=2[CH3:24])=[CH:4][CH:3]=1.Cl.[NH2:26][C:27]1([C:32]([NH2:34])=[O:33])[CH2:31][CH2:30][CH2:29][CH2:28]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[Cl:20])[N:11]=[C:10]([C:21]3[NH:34][C:32](=[O:33])[C:27]4([CH2:31][CH2:30][CH2:29][CH2:28]4)[N:26]=3)[C:9]=2[CH3:24])=[CH:6][CH:7]=1

Komponenten

3

Edukt 2

HCID 15194215-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acidHCID 545931881-Aminocyclopentane-1-carboxamide hydrochloride

Produkt 1

HCID 461988822-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazol-3-yl]-1,3-diaza-spiro[4.4]non-1-en-4-one

Versuchsvorschrift

Compound 25 was synthesized from 4a (251 mg, 0.66 mmol) and 5j (140 mg, 0.98 mmol) as a white solid (140 mg, 45%) in a manner similar to that described in Example 53. 1H NMR (400 MHz, CDCl3) δ 7.40 (d, 1H), 7.32˜7.26 (m, 3H), 7.12 (s, 1H), 7.02 (d, 2H), 2.49 (m, 2H), 2.36 (s, 3H), 2.17 (m, 2H), 1.86 (m, 4H); ESMS m/z: 473.1 (M+1).

Quellen und Nachweise

ORD-Eintrag
ord-02cc754c69104117a92e1091c8875902
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354442B2

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