Chlorosulfonyl isocyanate → Thieno[2,3-d]pyrimidine-2,4-diol

Reaktionsgleichung

ClC1N=C(N2CC[O:14][CH2:13]C2)C2C=CSC=2N=1.[NH2:17][C:18]1(C(OC)=O)[CH2:22][CH:21]=[CH:20][S:19]1.ClS([N:31]=[C:32]=[O:33])(=O)=O>>[NH:17]1[C:18]2[S:19][CH:20]=[CH:21][C:22]=2[C:13](=[O:14])[NH:31][C:32]1=[O:33]

Komponenten

Edukt 3

HCID 70918Chlorosulfonyl isocyanate

HCID 130381892-Chloro-4-(morpholin-4-yl)thieno(2,3-d)pyrimidine

HCID 68732898HCID 68732898, Verbindung

Produkt 1

HCID 12217323Thieno[2,3-d]pyrimidine-2,4-diol

Versuchsvorschrift

Scheme 6 shows the synthesis of 4-(2-chlorothieno[2,3-d]pyrimidin-4-yl)morpholine 18 starting by cyclization of methyl 2-amino-thiophenecarboxylate 15 (95 g) with chlorosulfonyl isocyanate at low temperature remains (−60° C. to −55° C.) to give thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione 16. Phosphorous oxychloride was added slowly to a cold solution of thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione 16 and N,N-dimethylaniline (0.75 equiv.) in acetonitrile while maintaining the temperature below 25° C. The mixture was then heated to 80-85° C. and stirred for 24 hours to afford dichlorothieno[2,3-d]pyrimidine 17. Morpholine (2.2 equiv.) was added to a solution of 2,4-dichlorothieno[2,3-d]pyrimidine 17 in methanol and stirred at ambient temperature for 1 h to give 18.