Propanal → HCID 66995125, Verbindung

HRID 1806066

Reaktionsgleichung

Reaktionsgleichung von HRID 1806066
[CH3:1][C:2]1[C:6]([N+:7]([O-:9])=O)=[C:5]([CH3:10])[O:4][N:3]=1.N1CC[CH2:14][CH2:13][CH2:12]1.C(=O)CC>CCO>[CH3:1][C:2]1[C:6]2=[N+:7]([O-:9])[C:13]([CH3:14])=[CH:12][CH:10]=[C:5]2[O:4][N:3]=1

Komponenten

5

Edukt 3

HCID 527PropanalHCID 8082PiperidineHCID 2614103,5-Dimethyl-4-nitroisoxazole

Produkt 1

HCID 66995125HCID 66995125, VerbindungAusbeute 225 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

3,5-dimethyl-4-nitroisoxazole (2.50 g, 17.6 mmol) in 25 mL EtOH was dissolved. Piperidine (0.174 mL, 1.76 mmol) was added followed by propionaldehyde (1.52 mL, 21.1 mmol). The solution was heated at 90° C. overnight. The solution was concentrated and chromatographed using EtOAc to obtain the title compound (0.650 g, 22.5% yield).

Aufarbeitung

  1. concentrationThe solution was concentrated
  2. customchromatographed

Quellen und Nachweise

ORD-Eintrag
ord-51ff40bc9e9b498190976f3bd8f4d816
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354540B2

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