Propionaldehyd

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious); polymerization hazard]:

Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

General First Aid:

Vapor is heavier than air ... & may travel a considerable distance to a source of ignition & flash back.

Can self-ignite if finely dispersed on porous or combustible material such as fabric.

· Wear positive pressure self-contained breathing apparatus (SCBA).

2070.0 [ppm]

A water spray may dilute to a point where combustion will not be supported. Water may be ineffective. Use alcohol foam, carbon dioxide, or dry chemical.

If fire becomes uncontrollable or container is exposed to direct flame consider evacuation of one-third (1/3) mile radius.

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped or safely confined. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide.

Fight fire from protected location or maximum possible distance. Use water spray to keep fire-exposed containers cool. Use water spray, dry chemical, "alcohol resistant" foam, or carbon dioxide. Water may be ineffective.

Store in cool, dry, well-ventilated location. Store away from heat and oxidizers. Outside or detached storage is preferred. Inside storage should be in a standard flammable liquids storage warehouse, room, or cabinet. Separate from oxidizing materials and other reactive hazards.

...Store in cool, well ventilated area away from oxidizers. Where possible, automatically pump liquid from drums or other storage containers to process containers...Metals containers involving the transfer of 5 gallons or more of this chemical should be grounded or bonded. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters. Use only non-sparking tools and equipment, especially when opening and closing containers of this chemical...

Eliminate all ignition sources. stop or control the leak, if this can be without undue risk. Use water spray to cool and disperse vapors, protect personnel, and dilute spills to form nonflammable mixtures. Control runoff and isolate discharged material for proper disposal.

Absorb the spills with rags or other available absorbing materials. Evaporate in hood and dispose by burning the rag or the absorbing materials.

...Absorb liquids in vermiculite, dry sand, earth, peat, carbon, or a similar material and deposit in sealed containers...

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Propionaldehyde is a waste chemical stream constituent which may be subjected to ultimate disposal by controlled incineration.

The following wastewater treatment technologies have been investigated for propionaldehyde: Activated carbon.

Guanethidine (G) is currently used in the treatment of essential hypertension. Acetaldehyde (A), acrolein (AR), formaldehyde (F) and propionaldehyde (P) are constituents of cigarette smoke and (A) is also an intermediate oxidative metabolite of ethanol. These aldehydes are known to produce sympathomimetic effects by the release of NE from adrenergic neurons and to exert cardioinhibitory effects. The type of predominant effect is dose-dependent. This study was undertaken to determine if these aldehydes result in sympathomimetic effects in the presence of G (15 mg/kg iv) in anesthetized rats. G enhanced the pressor responses to A and P in dose ranges of 5-20 and 5-10 mg/kg respectively. However, AR and F at dose ranges of 0.05-5 and 0.1-10 mg/kg, respectively, elicited only depressor responses after G. Thus, A and P exerted greater sympathomimetic effects through the release of intraneuronal NE in the presence of G. The adrenergic neuronal blocking action of G changes the blood pressure effects of AR and F. When these two compounds are administered in the absence of G, they cause predominant pressor effects, whereas in the presence of G a depressor response is noted. This depressor response is possibly by vagal stimulation and/or direct vasodilation.

EC50; Species: Pseudokirchneriella subcapitata (Green algae, exponential growth phase, 15000 cells/mL, UTEX 1648); Conditions: static, 24 °C, dissolved oxygen 1-2 mg/L; Concentration: 11380 ug/L for 48 hr; Effect: decreased photosynthesis

EC50; Species: Pseudokirchneriella subcapitata (Green algae, exponential growth phase, 15000 cells/mL, UTEX 1648); Conditions: static, 24 °C, dissolved oxygen 1-2 mg/L; Concentration: 24950 ug/L for 48 hr; Effect: decreased population growth rate

LC50; Species: Lepomis macrochirus (Bluegill, length 33-75 mm); Conditions: freshwater, static, 23 °C, pH 7.6-7.9, hardness 55 mg/L CaCO3; Concentration: 130000 ug/L for 96 hr

LC50; Species: Menidia beryllina (Inland silverside, length 40-100 mm); Conditions: saltwater, static, 20 °C, pH 7.6-7.9, hardness 55 mg/L CaCO3; Concentration: 100000 ug/L for 96 hr

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 50(SRC), determined from a log Kow of 0.59(2) and a regression-derived equation(3), indicates that propionaldehyde is expected to have very high mobility in soil(SRC). Volatilization of propionaldehyde from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 7.34X10-5 atm-cu m/mole(4). Propionaldehyde is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 317 mm Hg(5). Propionaldehyde reached 94% of its theoretical BOD in 4 weeks using an activated sludge inoculum in the Japanese MITI test, suggesting that biodegradation may be an important environmental fate process in soil(SRC). Propionaldehyde degrades by anaerobic biological treatment with 26% utilization being reported in a system with a 20 day hydraulic retention time(7).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 50(SRC), determined from a log Kow of 0.59(2) and a regression-derived equation(3), indicates that propionaldehyde is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 7.34X10-5 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 11 hrs and 5.8 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Propionaldehyde reached 94% of its theoretical BOD in 4 weeks using an activated sludge inoculum in the Japanese MITI test(7), suggesting that biodegradation may be an important environmental fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), propionaldehyde, which has a vapor pressure of 317 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase propionaldehyde is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 18 or 20 hrs(SRC), calculated from rate constants of 2.11X10-11 cu cm/molecule-sec(3) and 1.96X10-11 cu cm/molecule-sec(4), respectively. The rate constant for the vapor-phase reaction of propionaldehyde with nitrate radical has been experimentally determined to be 6.0X10-13 cu cm/sec(3). This corresponds to an atmospheric half-life of about 1.3 hrs(SRC). The direct photolysis rate constant for propionaldehyde in air is about 4X10-5 sec-1(5), which corresponds to a half-life of about 4.8 hrs(SRC).

Cough. Sore throat.

Redness. Pain.

Redness. Pain.

Burning sensation.

Propionaldehyde emission rates from dry-process photocopy machines were detected at concns ranging from <100 to 260 ug/hr(1). Propionaldehyde was detected in non-catalyst and catalyst equipped gasoline engine exhaust at 0.10 and 0.06% by weight of total organic gas emissions, respectively(2). Propionaldehyde was detected in commercial jet aircraft exhaust at 1.0% by weight of total organic gas emissions(2). Propionaldehyde concns from automobile exhaust were 3.4-150 ppbv in models from 1971, 1975, and 1977(3). Propionaldehyde emissions from a two stroke engine (chainsaw) using aliphatic gasoline, regular gasoline, and ethanol were 0.039-0.027, 0.062-0.089, and 0.022-0.038 g/kWhr, respectively(4). Using the same two stroke engine, emissions of propionaldehyde from aliphatic gasoline mixed with ethanol at 15, 50, and 85% were 0.039-0.065, 0.036-0.052, and 0.027-0.042 g/kWhr, respectively, and regular gasoline mixed with ethanol at 15, 50, and 85% were 0.067-0.087, 0.053-0.076, and 0.031-0.044 g/kWhr, respectively(4). Propionaldehyde was measured in the emissions of burnt wood at 255, 153, and 155 mg/kg of pine, oak, and eucalyptus, respectively(5). Propionaldehyde emissions from an automobile running on Swedish environmental classified diesel fuel were 3.2 mg/km and the same automobile running on European program emissions fuel were 3.4 mg/km(6).

Propionaldehyde

Nervous

8 x 10 ^-3 mg/m^3

Propionaldehyde is a food additive permitted for direct addition to food for human consumption as a synthetic flavoring substance and adjuvant in accordance with the following conditions: a) they are used in the minimum quantity required to produce their intended effect, and otherwise in accordance with all the principles of good manufacturing practice, and 2) they consist of one or more of the following, used alone or in combination with flavoring substances and adjuvants generally recognized as safe in food, prior-sanctioned for such use, or regulated by an appropriate section in this part.

Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, exposure, and use to EPA as cited in the preamble in 51 FR 41329. Effective date 9/30/91; Reporting date: 11/2791.

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Propanal is included on this list. Effective date 9/30/91; Sunset date: 6/30/98.

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Propionaldehyde is produced, as an intermediate or a final product, by process units covered under this subpart.

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Propionaldehyde is included on this list.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1000 lb or 454 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

Propionaldehyde is used in the manufacture of plastics, in the synthesis of rubber chemicals, and as a disinfectant and preservative.

Used to make propionic acid, trimethylolethane, polyvinyl and other plastics, and rubber, medicinal, and agricultural chemicals; Also used as a disinfectant, preservative, and flavoring agent; [HSDB] Used as a chemical intermediate in closed systems and not contained in consumer products; [AIHA] Used almost exclusively (thought to be >99%) as a closed system intermediate and transported by bulk carrier; [OECD SIDS]

Using Disinfectants or Biocides [Category: Clean]

For Propionaldehyde (USEPA/OPP Pesticide Code: 202400) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

Intermediate in the mfr of trimethylolethane for use in alkyd resin systems and, in certain cases, it is oxidized to propionic acid and reduced to propyl alcohol; in medicinal and agricultural chemical preparations.

Manufacture of propionic acid, polyvinyl and other plastics; synthesis of rubber chemicals; disinfectant; preservative

2023: 1,000,000,000 - <2,500,000,000 lb

(1972) 5.3X10+10 GRAMS

(1984) 1.02X10+11 g

Propanal is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and/or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B; 51FR21438).

Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#2978]

Prepared by treating propyl alcohol with a bichromate oxidizing mixture; ... by passing propyl alcohol vapor over copper at high temp.

Synthesis by ... dry distillation of barium propionate with calcium formate.

(A) Oxidation of propyl alcohol with dichromate; (B) By passing alcohol over copper at elevated temperatures.

Ethylene and synthesis gas (hydroformylation)

USEPA/OPP Pesticide Code 202400; Trade Names: Propanal.

Purity: 97-99+%.

Fragrance Ingredients

Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes

Flavoring Agents -> JECFA Flavorings Index

Paint and Coating Manufacturing

Propanal: ACTIVE

Synthetic flavoring substances & adjuvants: propionaldehyde