HCID 66723115, Verbindung → HCID 57732742, Verbindung

HRID 1806473Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1806473
[CH2:1]([S:3]([N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[C:20]3[C:15](=[C:16]([C:35]([NH2:37])=[O:36])[CH:17]=[C:18]([C:21]4[CH:26]=[CH:25][CH:24]=[C:23]([CH2:27][NH:28][C:29](=[O:34])CCCC)[CH:22]=4)[CH:19]=3)[NH:14][CH:13]=2)[CH2:8][CH2:7]1)(=[O:5])=[O:4])[CH3:2].CC1(C)C(C)(C)OB(C2C=[C:48]([CH2:52][NH:53][C:54](=[O:59])[CH2:55]CCC)[CH:49]=[CH:50][CH:51]=2)O1>>[C:54]([N:53]1[CH2:52][CH2:48][CH:49]([C:29]([NH:28][CH2:27][C:23]2[CH:22]=[C:21]([C:18]3[CH:19]=[C:20]4[C:15](=[C:16]([C:35]([NH2:37])=[O:36])[CH:17]=3)[NH:14][CH:13]=[C:12]4[CH:9]3[CH2:8][CH2:7][N:6]([S:3]([CH2:1][CH3:2])(=[O:4])=[O:5])[CH2:11][CH2:10]3)[CH:26]=[CH:25][CH:24]=2)=[O:34])[CH2:50][CH2:51]1)(=[O:59])[CH3:55]

Komponenten

3

Edukt 2

HCID 66723115HCID 66723115, VerbindungHCID 66723251HCID 66723251, Verbindung

Produkt 1

HCID 57732742HCID 57732742, Verbindung

Versuchsvorschrift

The title compound was prepared according to the general procedure of 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-{3-[(pentanoylamino)methyl]phenyl}-1H-indole-7-carboxamide substituting 1-acetyl-N-{[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}-4-piperidinecarboxamide (56 mg, 0.144 mmol) for N-{[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}pentanamide. Compound was purified by Gilson Preparatory HPLC to give the title compound.

Aufarbeitung

  1. customThe title compound was prepared
  2. customCompound was purified by Gilson Preparatory HPLC

Quellen und Nachweise

ORD-Eintrag
ord-ad6a6d6e4e714f24a9c57c4bb07c173d
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354406B2

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