2-Chlorobenzimidazole → tert-Butyl 2-(((1H-benzo[d]imidazol-2-yl)amino)methyl)piperidine-1-carboxylate

https://huagongshe.com/de/reaction/18074

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	2-Chlorobenzimidazole	HCID 78572	—
Edukt	tert-Butyl 2-(aminomethyl)piperidine-1-carboxylate	HCID 2756482	—
Produkt	tert-Butyl 2-(((1H-benzo[d]imidazol-2-yl)amino)methyl)piperidine-1-carboxylate	HCID 71631700	30,8%

Reaktionsbedingungen

Temperatur	100 °C

Reaktionsschritte

(RS)-2-Aminomethyl-piperidine-1-carboxylic acid tert butyl ester (0.25 g) and 2-chlorobenzimidazole (0.15 g) were combined and warmed to 100° C. for 48 hours. After cooling to room temperature the mixture was column chromatographed (silica gel, ethyl acetate/pentane 1:4-ethyl acetate/pentane 1:1 eluant) to give the title compound (0.1 g).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07741329B2
Quelldatensatz	uspto-grants-2010_06
ORD ID	ord-cefcc925e2ad409b8db8b21058d013d6
Quellennotiz	uspto-grants-2010_06