HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-Fluoro-4-(trifluoromethoxy)benzylamine → N-[3-fluoro-4-(trifluoromethoxy)benzyl]-4-[(1,2,4-thiadiazol-5-ylamino)sulfonyl]benzamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-Fluoro-4-(trifluoromethoxy)benzylamine | HCID 17750674 | — |
| Edukt | 4-[(1,2,4-Thiadiazol-5-ylamino)sulfonyl]benzoic acid | HCID 57732214 | — |
| Produkt | N-[3-fluoro-4-(trifluoromethoxy)benzyl]-4-[(1,2,4-thiadiazol-5-ylamino)sulfonyl]benzamide | HCID 57732217 | — |
Reaktionsschritte
The title compound was prepared from 4-[(1,2,4-thiadiazol-5-ylamino)sulfonyl]benzoic acid (Preparation 29) and 3-fluoro-4-(trifluoromethoxy)benzylamine following the procedure described in Example 309. The reaction mixture was extracted from saturated sodium hydrogen carbonate into DCM and the crude product purified by preparative HPLC.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08357711B2 |
| Quelldatensatz | uspto-grants-2013_01 |
| ORD ID | ord-698c2660e809466c887e6555b924a85c |
| Quellennotiz | uspto-grants-2013_01 |