1,4-Dioxane hydrochloride → 6-(2-Fluorobenzyl)-1,4-oxazepan-6-ol Hydrochloride

HRID 1808205Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1808205
[F:1][C:2]1[CH:23]=[CH:22][CH:21]=[CH:20][C:3]=1[CH2:4][C:5]1([OH:19])[CH2:11][O:10][CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6]1.[ClH:24].O1CCOCC1>O1CCOCC1>[ClH:24].[F:1][C:2]1[CH:23]=[CH:22][CH:21]=[CH:20][C:3]=1[CH2:4][C:5]1([OH:19])[CH2:11][O:10][CH2:9][CH2:8][NH:7][CH2:6]1

Komponenten

4

Edukt 2

HCID 204431481,4-Dioxane hydrochlorideHCID 57731942tert-Butyl 6-(2-fluorobenzyl)-6-hydroxy-1,4-oxazepane-4-carboxylate

Produkt 1

HCID 685346716-(2-Fluorobenzyl)-1,4-oxazepan-6-ol HydrochlorideAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

tert-Butyl 6-(2-fluorobenzyl)-6-hydroxy-1,4-oxazepane-4-carboxylate (Preparation 45, 38 g, 0.12 mol, 1 eq) was dissolved in dioxane (200 mL), and 4M hydrogen chloride/dioxane (60.4 mL, 0.24 mol, 2 eq) was added. The mixture was stirred for 24 h, evaporated, and coevaporated with ether. The formed precipitate was washed with ether and dried to give title compound (29.8 g, 0.11 mol, 95%).

Aufarbeitung

  1. customevaporated
  2. washThe formed precipitate was washed with ether
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-0abe11a47c6e4ebd98a495c79d0e290a
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08357711B2

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