Methylparaben → Methyl 4-{[2-(dimethylamino)-2-oxoethyl]oxy}benzoate

HRID 1808560Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1808560
[OH:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Cl[CH2:19][C:20]([N:22]([CH3:24])[CH3:23])=[O:21]>CN(C=O)C>[CH3:23][N:22]([CH3:24])[C:20](=[O:21])[CH2:19][O:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:10][CH:11]=1

Komponenten

5

Edukt 3

HCID 7456MethylparabenHCID 11430Potassium Carbonate2×HCID 758862-chloro-N,N-dimethylacetamide2×

Produkt 1

HCID 45792893Methyl 4-{[2-(dimethylamino)-2-oxoethyl]oxy}benzoateAusbeute 68,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

Methyl 4-hydroxybenzoate (Fluka) (1.52 g, 10 mmol) and potassium carbonate (1.38 g, 10 mmol) in DMF (10 mL) was treated with 2-chloro-N,N-dimethylacetamide (Merck) (1.03 ml, 10 mmol) and the mixture was stirred at RT overnight. The reaction mixture was worked up by partitioning between ethyl acetate and 2M hydrochloric acid, washing with HCl, brine, dried (MgSO4) and evaporating to dryness. The residue was dissolved in DMF (5 mL) and treated with potassium carbonate (1.38 g, 10 mmol) and 2-chloro-N,N-dimethylacetamide (Merck) (1.03 ml, 10 mmol). The mixture was stirred at RT over the weekend, and then worked up. Partitioned between ethyl acetate and 2M HCl and the organic solution was washed with HCl (×2), brine (×3), dried (MgSO4), and evaporated to give the title compound (1.62 g, 68%) as a white solid. LCMS (System A) RT=0.73 min, ES+ve m/z 238 (M+H)+.

Aufarbeitung

  1. customby partitioning between ethyl acetate and 2M hydrochloric acid
  2. washwashing with HCl, brine
  3. dry with materialdried (MgSO4)
  4. customevaporating to dryness
  5. dissolutionThe residue was dissolved in DMF (5 mL)
  6. stirringThe mixture was stirred at RT over the weekend
  7. customPartitioned between ethyl acetate and 2M HCl
  8. washthe organic solution was washed with HCl (×2), brine (×3)
  9. dry with materialdried (MgSO4)
  10. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-bc74297baede4fbeab85d66b31ca767e
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08357716B2

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