Imidazole → HCID 14419323, Verbindung

HRID 1808670Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1808670
[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.[H-].[Na+].I[CH2:9][CH2:10][CH2:11][Si:12]([O:17][CH3:18])([O:15][CH3:16])[O:13][CH3:14].ClCCl>O1CCCC1>[CH3:14][O:13][Si:12]([CH2:11][CH2:10][CH2:9][C:2]1[NH:1][CH:5]=[CH:4][N:3]=1)([O:17][CH3:18])[O:15][CH3:16]

Komponenten

6

Edukt 4

HCID 795ImidazoleHCID 6344DichloromethaneHCID 24758Sodium hydrideHCID 2759373(3-Iodopropyl)trimethoxysilane

Produkt 1

HCID 14419323HCID 14419323, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

5 g (73 mmol) of imidazole were dissolved in 100 ml of tetrahydrofurane and 1.73 g (73 mmol) of sodium hydride were added. The suspension was stirred for 4 hours, after which 10 ml of iodopropyltrimethoxy silane (52 mmol) were added and the reaction mixture was heated under reflux for 18 hours. 15 ml of dichloromethane were then added and the reaction mixture was filtered. The filtrate was concentrated under reduced pressure and the product was distilled off at 150-155° C. at 8 mbar. The yield was 8.2 g (60%).

Aufarbeitung

  1. temperaturethe reaction mixture was heated
  2. temperatureunder reflux for 18 hours
  3. filtrationthe reaction mixture was filtered
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. distillationthe product was distilled off at 150-155° C. at 8 mbar

Quellen und Nachweise

ORD-Eintrag
ord-38adc40401b7427a9df5599cad9438fb
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08361627B2

Notizen zur Reaktion

Wird geladen…