1-Benzyl 4-tert-butyl 5,6-dimethyl-1,4-diazepane-1,4-dicarboxylate → Tert-butyl 6,7-dimethyl-1,4-diazepane-1-carboxylate

HRID 1808914Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1808914
[CH3:1][CH:2]1[CH:8]([CH3:9])[CH2:7][N:6](C(OCC2C=CC=CC=2)=O)[CH2:5][CH2:4][N:3]1[C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21].[H][H]>C(OCC)(=O)C.[OH-].[OH-].[Pd+2]>[CH3:9][CH:8]1[CH:2]([CH3:1])[N:3]([C:20]([O:22][C:23]([CH3:25])([CH3:24])[CH3:26])=[O:21])[CH2:4][CH2:5][NH:6][CH2:7]1

Komponenten

5

Edukt 2

HCID 684245271-Benzyl 4-tert-butyl 5,6-dimethyl-1,4-diazepane-1,4-dicarboxylateHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 59527658Tert-butyl 6,7-dimethyl-1,4-diazepane-1-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 1-3 (3.3 g, 9.1 mmol) in ethyl acetate (45 mL) was added 20% palladium hydroxide on carbon (256 mg) and the reaction was stirred at room temperature under balloon pressure of hydrogen gas overnight. The reaction was filtered through celite and concentrated in vacuo to afford 1-4.

Aufarbeitung

  1. filtrationThe reaction was filtered through celite and
  2. concentrationconcentrated in vacuo
  3. customto afford 1-4

Quellen und Nachweise

ORD-Eintrag
ord-511a89bcc0d640cf9be3f0e9b4c144d8
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08362009B2

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