Diethyl 1,1-cyclobutanedicarboxylate → Ethyl 1-(hydroxymethyl)cyclobutane-1-carboxylate

HRID 1809427

Reaktionsgleichung

Reaktionsgleichung von HRID 1809427
[Li+].CC(O[Al-](OC(C)(C)C)OC(C)(C)C)(C)C.[C:18]1([C:27](OCC)=[O:28])([C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH2:21][CH2:20][CH2:19]1.OS([O-])(=O)=O.[K+]>C1COCC1.C(OCC)(=O)C>[CH2:25]([O:24][C:22]([C:18]1([CH2:27][OH:28])[CH2:21][CH2:20][CH2:19]1)=[O:23])[CH3:26]

Komponenten

6

Edukt 3

HCID 77410Diethyl 1,1-cyclobutanedicarboxylateHCID 516920Potassium bisulfateHCID 16688073Lithium aluminum-tri-tert-butoxyhydride

Produkt 1

HCID 15670506Ethyl 1-(hydroxymethyl)cyclobutane-1-carboxylateAusbeute 63,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8028TetrahydrofuranLösungsmittel2×HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A solution of lithium aluminum-tri-tert-butoxyhydride 1.0M in THF (100.0 mL, 100.0 mmol) is added at −78° C. to a solution of diethyl 1,1-cyclobutanedicarboxylate (10.0 g, 50.0 mmol) in anhydrous THF (50.0 mL). After stirring the reaction mixture at room temperature for 14 h, 10% aq. KHSO4 solution is added and the reaction mixture diluted with ethyl acetate. After separating the two phases, the organic phase is washed with water and brine and dried over anhydrous Na2SO4. Filtration and removal of the solvent under reduced pressure affords 5.0 g of 1-hydroxymethyl-cyclobutanecarboxylic acid ethyl ester that is used in the next step without further purification. Yield: 63%; m/z 159 [M+H].

Aufarbeitung

  1. customAfter separating the two phases
  2. washthe organic phase is washed with water and brine
  3. dry with materialdried over anhydrous Na2SO4
  4. filtrationFiltration and removal of the solvent under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-6a87c1386f08414da8609056a9cbbd11
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08362039B2

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