Trifluoroacetic acid → HCID 67089785, Verbindung

HRID 18095Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 18095
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][NH:15][C:16]1[N:17]=[C:18]2[CH:25]=[CH:24][CH:23]=[N:22][C:19]2=[N:20][CH:21]=1)=O)(C)(C)C.[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29]>ClCCl>[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29].[NH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][NH:15][C:16]1[N:17]=[C:18]2[CH:25]=[CH:24][CH:23]=[N:22][C:19]2=[N:20][CH:21]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 69284289(Pyrido[2,3-b]pyrazin-2-ylaminomethyl)-piperidine-1-carboxylic acid tert butyl ester

Produkt 1

HCID 67089785HCID 67089785, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

2-(Pyrido[2,3-b]pyrazin-2-ylaminomethyl)-piperidine-1-carboxylic acid tert butyl ester (0.48 g) was dissolved in dichloromethane (3 ml), cooled (ice bath) and treated with trifluoroacetic acid (2 ml). The mixture was stirred for 3 hours at room temperature, solvent removed at reduced pressure and the residue co-evaporated with toluene to give the title compound (0.45 g).

Aufarbeitung

  1. temperaturecooled (ice bath)
  2. customsolvent removed at reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-fc60f30ac7954d81b9a4604df3ee0f47
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741329B2

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