Potassium Carbonate → 1-(3-Phenoxy-5-(pyridin-2-ylthio)pyridin-2-yl)thiourea

HRID 1809580Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1809580
C([NH:9][C:10]([NH:12][C:13]1[C:18]([O:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:17][C:16]([S:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=2)=[CH:15][N:14]=1)=[S:11])(=O)C1C=CC=CC=1.C([O-])([O-])=O.[K+].[K+]>CCO>[O:19]([C:18]1[C:13]([NH:12][C:10]([NH2:9])=[S:11])=[N:14][CH:15]=[C:16]([S:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=2)[CH:17]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Komponenten

4

Edukt 2

HCID 11430Potassium CarbonateHCID 866410891-Benzoyl-3-(3-phenoxy-5-(pyridin-2-ylthio)pyridin-2-yl)thiourea

Produkt 1

HCID 866410901-(3-Phenoxy-5-(pyridin-2-ylthio)pyridin-2-yl)thioureaAusbeute 29,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 1-benzoyl-3-(3-phenoxy-5-(pyridin-2-ylthio)pyridin-2-yl)thiourea (2.10 g, 4.58 mmol) and K2CO3 (3.16 g, 22.9 mmol) was refluxed in EtOH (50 mL) for 18 hours. The reaction was cooled to ambient temperature, filtered and concentrated. The residue was purified by silica gel to provide 1-(3-phenoxy-5-(pyridin-2-ylthio)pyridin-2-yl)thiourea (0.484 g, 29.8% yield).

Aufarbeitung

  1. filtrationfiltered
  2. concentrationconcentrated
  3. customThe residue was purified by silica gel

Quellen und Nachweise

ORD-Eintrag
ord-7350c94515b844f889bd51dcab7af746
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08362037B2

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