Hydrazine → HCID 178478326, Verbindung

HRID 1809661Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1809661
Br[C:2]1[C:3](Cl)=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1.[Br:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=1)[CH:14]=O.[NH2:19][NH2:20]>>[Br:10][C:11]1[CH:12]=[C:13]([C:14]2[C:2]3[C:3](=[N:4][C:5]([Cl:8])=[N:6][CH:7]=3)[NH:20][N:19]=2)[CH:16]=[CH:17][CH:18]=1

Komponenten

4

Edukt 3

HCID 9321HydrazineHCID 765833-BromobenzaldehydeHCID 2899735-Bromo-2,4-dichloropyrimidine

Produkt 1

HCID 178478326HCID 178478326, Verbindung

Versuchsvorschrift

Alternatively, for compounds of formula Ib where X and Y are CH, in accordance to Scheme 3 below, 5-bromo-2,4-dichloro-pyrimidine (1) is reacted with 3-bromo-benzaldehyde (4) by a Grignard reaction and the corresponding coupled alcohol is oxidized to the ketone. The ketone is reacted with hydrazine to give 3-(3-bromo-phenyl)-6-chloro-1H-pyrazolo[3,4-d]pyrimidine. The remaining chloro group can then be replaced by reacting with the appropriate amine and the bromide can be displacement with the required amine under Buckwald conditions to give compounds Ib of this invention.

Quellen und Nachweise

ORD-Eintrag
ord-aef62ac29587452a9a6b8da7027f7210
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08362023B2

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