Hydrazine → HCID 178478326, Verbindung

HRID 1809706Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1809706
[Br:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[C:11](Cl)=[N:12][C:13]([Cl:16])=[N:14][CH:15]=2)=O)[CH:5]=[CH:6][CH:7]=1.[NH2:18][NH2:19]>C1COCC1>[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[C:10]3[C:11](=[N:12][C:13]([Cl:16])=[N:14][CH:15]=3)[NH:19][N:18]=2)[CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 9321HydrazineHCID 86667963(3-Bromo-phenyl)-(2,4-dichloro-pyrimidin-5-yl)-methanone

Produkt 1

HCID 178478326HCID 178478326, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of crude (3-bromo-phenyl)-(2,4-dichloro-pyrimidin-5-yl)-methanone (from Example 37 supra) (1 g, 3.0 mmol) in THF (70 mL), 85% hydrazine (0.45 g, 7.64 mmol) was added dropwise at room temperature. The mixture was stirred for additional 20 minutes at room temperature and then heated at 50° C. for another 20 minutes. The solvent was removed under reduced pressure, and the residue was washed with water (5 mL), petroleum ether (10 mL) and dried to give 3-(3-bromo-phenyl)-6-chloro-1H-pyrazolo[3,4-d]pyrimidine as yellow solid. (Yield 0.848 g, 91.3%).

Aufarbeitung

  1. temperatureheated at 50° C. for another 20 minutes
  2. customThe solvent was removed under reduced pressure
  3. washthe residue was washed with water (5 mL), petroleum ether (10 mL)
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-f54074799a7842a6b91d82b9eebb7c24
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08362023B2

Notizen zur Reaktion

Wird geladen…