Hydrochloric Acid → HCID 178511334, Verbindung

HRID 1809762Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1809762
C(OC(=O)[NH:7][CH2:8][CH:9]([C:35]1[CH:40]=[CH:39][CH:38]=[C:37]([Cl:41])[CH:36]=1)[NH:10][C:11]1[N:16]=[C:15]([C:17]2[C:25]3[C:20](=[N:21][C:22]([NH:26][CH2:27][CH2:28][N:29]4[CH2:34][CH2:33][O:32][CH2:31][CH2:30]4)=[N:23][CH:24]=3)[NH:19][N:18]=2)[CH:14]=[CH:13][N:12]=1)(C)(C)C.Cl>CCO>[Cl:41][C:37]1[CH:36]=[C:35]([CH:9]([NH:10][C:11]2[N:16]=[C:15]([C:17]3[C:25]4[C:20](=[N:21][C:22]([NH:26][CH2:27][CH2:28][N:29]5[CH2:30][CH2:31][O:32][CH2:33][CH2:34]5)=[N:23][CH:24]=4)[NH:19][N:18]=3)[CH:14]=[CH:13][N:12]=2)[CH2:8][NH2:7])[CH:40]=[CH:39][CH:38]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 178453678HCID 178453678, Verbindung

Produkt 1

HCID 178511334HCID 178511334, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

(2-(3-Chloro-phenyl)-2-{4-[6-(2-morpholin-4-yl-ethylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-pyrimidin-2-ylamino}-ethyl)-carbamic acid tert-butyl ester (100 mg, 0.17 mmol) was dissolved in EtOH (4 mL), then HCl (4 mL) was added. The reaction mixture was stirred at room temperature for 10 hours. The solvent was removed under reduced pressure to afford the crude product which was purified by prep-HPLC to afford 1-(3-chloro-phenyl)-N1-{4-[6-(2-morpholin-4-yl-ethylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-pyrimidin-2-yl}-ethane-1,2-diamine; hydrochloride. (Yield 24 mg, 23.7%).

Aufarbeitung

  1. customThe solvent was removed under reduced pressure
  2. customto afford the crude product which
  3. customwas purified by prep-HPLC

Quellen und Nachweise

ORD-Eintrag
ord-89dd80a6721d4ae7980456cd34654d6a
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08362023B2

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