Hydrochloric Acid → HCID 178478112, Verbindung

HRID 1809779Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1809779
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[N:20]=[C:19]3[NH:21][N:22]=[C:23]([C:24]4[CH:29]=[CH:28][N:27]=[C:26]([NH:30][CH2:31][C:32]5[CH:37]=[CH:36][CH:35]=[C:34]([Cl:38])[CH:33]=5)[N:25]=4)[C:18]3=[CH:17][N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>CCO>[Cl:38][C:34]1[CH:33]=[C:32]([CH:37]=[CH:36][CH:35]=1)[CH2:31][NH:30][C:26]1[N:25]=[C:24]([C:23]2[C:18]3[C:19](=[N:20][C:15]([NH:14][CH:11]4[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]4)=[N:16][CH:17]=3)[NH:21][N:22]=2)[CH:29]=[CH:28][N:27]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 178452083HCID 178452083, Verbindung

Produkt 1

HCID 178478112HCID 178478112, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 4-{3-[2-(3-chloro-benzylamino)-pyrimidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino}-piperidine-1-carboxylic acid tert-butyl ester (80 mg, 0.15 mmol) in EtOH (4 mL) was added conc. HCl (4 mL). The reaction mixture was stirred at room temperature for 15 hours. The solvent was then removed and the residue was purified by prep-HPLC to afford {3-[2-(3-chloro-benzylamino)-pyrimidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-piperidin-4-yl-amine; hydrochloride. (Yield 20 mg, 26.3%).

Aufarbeitung

  1. customThe solvent was then removed
  2. customthe residue was purified by prep-HPLC

Quellen und Nachweise

ORD-Eintrag
ord-8fc61330bcf141359db1db101175c8e7
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08362023B2

Notizen zur Reaktion

Wird geladen…