Hydrochloric Acid → (3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester

HRID 1810309Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1810309
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH2:19][C:20]([OH:22])=[O:21])[CH:12]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[CH3:24]O>O1CCOCC1>[CH3:24][O:21][C:20](=[O:22])[CH2:19][C:11]1[CH:12]=[C:13]([C:15]([F:17])([F:18])[F:16])[CH:14]=[C:9]([O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH:10]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 59644613(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid

Produkt 1

HCID 58149337(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To a solution of (3-benzyloxy-5-trifluoromethyl-phenyl)-acetic acid (1.5 g, 4.8 mmol) in MeOH (10 mL) was added 4N HCl in 1,4-dioxane (2 mL), and the reaction was stirred at 80° C. for 1 hour. The mixture was concentrated and purified by silica gel chromatography to give the title compound.

Aufarbeitung

  1. concentrationThe mixture was concentrated
  2. custompurified by silica gel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-f682cdeaf7f448dfb8998b6cbbfcf36c
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08362044B2

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